Contribution of genetic factors in the occurrence of breast cancer in cuban women
DOI:
https://doi.org/10.56294/dm202275Keywords:
Breast Neoplasms, Risk Factors, Genetic Predisposition to DiseaseAbstract
Introduction: breast cancer is a disease of multifactorial etiology, where genetic factors and environmental factors are involved, in Cuba it constitutes the second cause of mortality in women "however" it is not known what the risk of a woman is developing it attributable to genetic predisposition, limiting an effective genetic counseling.
Objective: to identify the preferential clustering of breast cancer in relatives of cases with respect to the population and to analyze the genetic contribution in people with breast cancer attended at the National Institute of Oncology and Radiobiology (INOR).
Methods: we conducted an analytical study of cases and nested neighborhood controls in a dynamic cohort. The sample consisted of 66 cases and 132 controls. The genetic contribution was studied through the tools of genetic epidemiology.
Results: there was a preferential clustering of this disease in families that, in the population, genetic factors defined the familial prevalence of breast cancer in the relatives of the cases and there was an increasing tendency to suffer the disease as the proportion of genes to be shared increases.
Conclusion: the preferential aggregation of breast cancer is identified and the contribution of genetic factors in the appearance of this disease in women attended at INOR is analyzed, showing that a person has three times more risk of suffering breast cancer attributable to the history of this disease in second-degree relatives
References
1. Olsson Möller U, Beck I, Rydén L, Malmström M. A comprehensive approach to rehabilitation interventions following breast cancer treatment - a systematic review of systematic reviews. BMC Cancer 2019; 19:472. https://doi.org/10.1186/s12885-019-5648-7.
2. Jang S, Ko Y, Sasaki Y, Park S, Jo J, Kang N-H, et al. Acupuncture as an adjuvant therapy for management of treatment-related symptoms in breast cancer patients: Systematic review and meta-analysis (PRISMA-compliant). Medicine (Baltimore) 2020;99:e21820. https://doi.org/10.1097/MD.0000000000021820.
3. Burstein HJ, Lacchetti C, Anderson H, Buchholz TA, Davidson NE, Gelmon KA, et al. Adjuvant Endocrine Therapy for Women With Hormone Receptor-Positive Breast Cancer: ASCO Clinical Practice Guideline Focused Update. J Clin Oncol Off J Am Soc Clin Oncol 2019;37:423-38. https://doi.org/10.1200/JCO.18.01160.
4. Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Abate D, Abbasi N, Abbastabar H, Abd-Allah F, et al. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol 2019;5:1749-68. https://doi.org/10.1001/jamaoncol.2019.2996.
5. Rodriguez RC, Esperon AA, Ropero R, Rubio MC, Rodriguez R, Ortiz RM, et al. Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Cuba. Fam Cancer 2008;7:275-9. https://doi.org/10.1007/s10689-008-9187-7.
6. Cullinane C, Fleming C, O’Leary DP, Hassan F, Kelly L, O’Sullivan MJ, et al. Association of Circulating Tumor DNA With Disease-Free Survival in Breast Cancer: A Systematic Review and Meta-analysis. JAMA Netw Open 2020;3:e2026921. https://doi.org/10.1001/jamanetworkopen.2020.26921.
7. Marchica P, D’Arpa S, Magno S, Rossi C, Forcina L, Capizzi V, et al. Integrated Treatment of Breast Cancer-related Lymphedema: A Descriptive Review of the State of the Art. Anticancer Res 2021;41:3233-46. https://doi.org/10.21873/anticanres.15109.
8. Carreira H, Williams R, Müller M, Harewood R, Stanway S, Bhaskaran K. Associations Between Breast Cancer Survivorship and Adverse Mental Health Outcomes: A Systematic Review. J Natl Cancer Inst 2018;110:1311-27. https://doi.org/10.1093/jnci/djy177.
9. Chang JM, Leung JWT, Moy L, Ha SM, Moon WK. Axillary Nodal Evaluation in Breast Cancer: State of the Art. Radiology 2020;295:500-15. https://doi.org/10.1148/radiol.2020192534.
10. Samiei S, Simons JM, Engelen SME, Beets-Tan RGH, Classe J-M, Smidt ML, et al. Axillary Pathologic Complete Response After Neoadjuvant Systemic Therapy by Breast Cancer Subtype in Patients With Initially Clinically Node-Positive Disease: A Systematic Review and Meta-analysis. JAMA Surg 2021;156:e210891. https://doi.org/10.1001/jamasurg.2021.0891.
11. Gardezi SJS, Elazab A, Lei B, Wang T. Breast Cancer Detection and Diagnosis Using Mammographic Data: Systematic Review. J Med Internet Res 2019;21:e14464. https://doi.org/10.2196/14464.
12. Hartley RL, Stone JP, Temple-Oberle C. Breast cancer in transgender patients: A systematic review. Part 1: Male to female. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol 2018;44:1455-62. https://doi.org/10.1016/j.ejso.2018.06.035.
13. Boing L, Vieira M de CS, Moratelli J, Bergmann A, Guimarães AC de A. Effects of exercise on physical outcomes of breast cancer survivors receiving hormone therapy - A systematic review and meta-analysis. Maturitas 2020;141:71-81. https://doi.org/10.1016/j.maturitas.2020.06.022.
14. Dandamudi A, Tommie J, Nommsen-Rivers L, Couch S. Dietary Patterns and Breast Cancer Risk: A Systematic Review. Anticancer Res 2018;38:3209-22. https://doi.org/10.21873/anticanres.12586.
15. Rocha G, Soares P, Gonçalves A, Silva AI, Almeida D, Figueiredo S, et al. Respiratory Care for the Ventilated Neonate. Can Respir J 2018;2018:7472964. https://doi.org/10.1155/2018/7472964.
16. Tsuji K, Matsuoka YJ, Ochi E. High-intensity interval training in breast cancer survivors: a systematic review. BMC Cancer 2021;21:184. https://doi.org/10.1186/s12885-021-07804-w.
17. Ma J-H, Qin L, Li X. Role of STAT3 signaling pathway in breast cancer. Cell Commun Signal CCS 2020;18:33. https://doi.org/10.1186/s12964-020-0527-z.
18. Thompson B, Gaitatzis K, Janse de Jonge X, Blackwell R, Koelmeyer LA. Manual lymphatic drainage treatment for lymphedema: a systematic review of the literature. J Cancer Surviv Res Pract 2021;15:244-58. https://doi.org/10.1007/s11764-020-00928-1.
19. GlobalSurg Collaborative and National Institute for Health Research Global Health Research Unit on Global Surgery. Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries. Lancet Lond Engl 2021;397:387-97. https://doi.org/10.1016/S0140-6736(21)00001-5.
20. Gibbon S. Family medicine, «La Herencia» and breast cancer; understanding the (dis)continuities of predictive genetics in Cuba. Soc Sci Med 1982 2011;72:1784-92. https://doi.org/10.1016/j.socscimed.2010.09.053.
21. Di Sibio A, Abriata G, Forman D, Sierra MS. Female breast cancer in Central and South America. Cancer Epidemiol 2016;44 Suppl 1:S110-20. https://doi.org/10.1016/j.canep.2016.08.010.
22. Fagundo-Rivera J, Gómez-Salgado J, García-Iglesias JJ, Gómez-Salgado C, Camacho-Martín S, Ruiz-Frutos C. Relationship between Night Shifts and Risk of Breast Cancer among Nurses: A Systematic Review. Med Kaunas Lith 2020;56:680. https://doi.org/10.3390/medicina56120680.
23. Hasenoehrl T, Keilani M, Palma S, Crevenna R. Resistance exercise and breast cancer related lymphedema - a systematic review update. Disabil Rehabil 2020;42:26-35. https://doi.org/10.1080/09638288.2018.1514663.
24. Hossain S, Beydoun MA, Beydoun HA, Chen X, Zonderman AB, Wood RJ. Vitamin D and breast cancer: A systematic review and meta-analysis of observational studies. Clin Nutr ESPEN 2019;30:170-84. https://doi.org/10.1016/j.clnesp.2018.12.085.
25. Pal A, Taneja N, Malhotra N, Shankar R, Chawla B, Awasthi AA, et al. Knowledge, attitude, and practice towards breast cancer and its screening among women in India: A systematic review. J Cancer Res Ther 2021;17:1314-21. https://doi.org/10.4103/jcrt.JCRT_922_20.
26. Urbano T, Vinceti M, Wise LA, Filippini T. Light at night and risk of breast cancer: a systematic review and dose-response meta-analysis. Int J Health Geogr 2021;20:44. https://doi.org/10.1186/s12942-021-00297-7.
27. Wei F, Chen W, Lin X. Night-shift work, breast cancer incidence, and all-cause mortality: an updated meta-analysis of prospective cohort studies. Sleep Breath Schlaf Atm 2022;26:1509-26. https://doi.org/10.1007/s11325-021-02523-9.
28. Beebeejaun Y, Athithan A, Copeland TP, Kamath MS, Sarris I, Sunkara SK. Risk of breast cancer in women treated with ovarian stimulation drugs for infertility: a systematic review and meta-analysis. Fertil Steril 2021;116:198-207. https://doi.org/10.1016/j.fertnstert.2021.01.044.
29. So WKW, Law BMH, Ng MSN, He X, Chan DNS, Chan CWH, et al. Symptom clusters experienced by breast cancer patients at various treatment stages: A systematic review. Cancer Med 2021;10:2531-65. https://doi.org/10.1002/cam4.3794.
30. Carbine NE, Lostumbo L, Wallace J, Ko H. Risk-reducing mastectomy for the prevention of primary breast cancer. Cochrane Database Syst Rev 2018;4:CD002748. https://doi.org/10.1002/14651858.CD002748.pub4.
31. Morgan AJ, Giannoudis A, Palmieri C. The genomic landscape of breast cancer brain metastases: a systematic review. Lancet Oncol 2021;22:e7-17. https://doi.org/10.1016/S1470-2045(20)30556-8.
32. Abdou Y, Elkhanany A, Attwood K, Ji W, Takabe K, Opyrchal M. Primary and secondary breast angiosarcoma: single center report and a meta-analysis. Breast Cancer Res Treat 2019;178:523-33. https://doi.org/10.1007/s10549-019-05432-4.
33. Atakpa EC, Thorat MA, Cuzick J, Brentnall AR. Mammographic density, endocrine therapy and breast cancer risk: a prognostic and predictive biomarker review. Cochrane Database Syst Rev 2021;10:CD013091. https://doi.org/10.1002/14651858.CD013091.pub2.
34. Jayasekera J, Mandelblatt JS. Systematic Review of the Cost Effectiveness of Breast Cancer Prevention, Screening, and Treatment Interventions. J Clin Oncol Off J Am Soc Clin Oncol 2020;38:332-50. https://doi.org/10.1200/JCO.19.01525.
35. Phung MT, Tin Tin S, Elwood JM. Prognostic models for breast cancer: a systematic review. BMC Cancer 2019;19:230. https://doi.org/10.1186/s12885-019-5442-6.
36. Tosello G, Torloni MR, Mota BS, Neeman T, Riera R. Breast surgery for metastatic breast cancer. Cochrane Database Syst Rev 2018;3:CD011276. https://doi.org/10.1002/14651858.CD011276.pub2.
37. Volders JH, Negenborn VL, Spronk PE, Krekel NMA, Schoonmade LJ, Meijer S, et al. Breast-conserving surgery following neoadjuvant therapy-a systematic review on surgical outcomes. Breast Cancer Res Treat 2018;168:1-12. https://doi.org/10.1007/s10549-017-4598-5.
38. Baumann FT, Reike A, Reimer V, Schumann M, Hallek M, Taaffe DR, et al. Effects of physical exercise on breast cancer-related secondary lymphedema: a systematic review. Breast Cancer Res Treat 2018;170:1-13. https://doi.org/10.1007/s10549-018-4725-y.
39. Carioli G, La Vecchia C, Bertuccio P, Rodriguez T, Levi F, Boffetta P, et al. Cancer mortality predictions for 2017 in Latin America. Ann Oncol Off J Eur Soc Med Oncol 2017;28:2286-97. https://doi.org/10.1093/annonc/mdx301.
40. Camargo MS, Prieto AM, Resende FA, Boldrin PK, Cardoso CRP, Fernández MF, et al. Evaluation of estrogenic, antiestrogenic and genotoxic activity of nemorosone, the major compound found in brown Cuban propolis. BMC Complement Altern Med 2013;13:201. https://doi.org/10.1186/1472-6882-13-201.
41. Seay JS, Carrasquillo O, Campos NG, McCann S, Amofah A, Pierre L, et al. Cancer Screening Utilization Among Immigrant Women in Miami, Florida. Prog Community Health Partnersh Res Educ Action 2015;9 Suppl:11-20. https://doi.org/10.1353/cpr.2015.0029.
42. Oliveira C, Garnacho Martins Nobre CF, Centro Hospitalar Universitário Lisboa Norte, EPE, Dourado Marques RM, Universidade Católica Portuguesa, Madureira Lebre Mendes MM, et al. O papel do enfermeiro na prevenção do delirium no paciente adulto/idoso crítico. Rev Cuid 2022. https://doi.org/10.15649/cuidarte.1983.
43. Ripperger T, Gadzicki D, Meindl A, Schlegelberger B. Breast cancer susceptibility: current knowledge and implications for genetic counselling. Eur J Hum Genet EJHG 2009;17:722-31. https://doi.org/10.1038/ejhg.2008.212.
44. Solera A, Tárraga, López M, Celada A, Carballo J, Cerdán M, et al. Factores hereditarios y cáncer colorrectal. Rev ACAD 2006;22:3-8.
45. Gajdosik Z. Racotumomab - a novel anti-idiotype monoclonal antibody vaccine for the treatment of cancer. Drugs Today Barc Spain 1998 2014;50:301-7. https://doi.org/10.1358/dot.2014.50.4.2116670.
46. Culp MB, Soerjomataram I, Efstathiou JA, Bray F, Jemal A. Recent Global Patterns in Prostate Cancer Incidence and Mortality Rates. Eur Urol 2020;77:38-52. https://doi.org/10.1016/j.eururo.2019.08.005.
47. Alvarez YHG, Yi MEG, Garrote LF, Rodríguez RC. Incidence, mortality and survival from prostate cancer in Cuba, 1977-1999. Eur J Cancer Prev Off J Eur Cancer Prev Organ ECP 2004;13:377-81. https://doi.org/10.1097/00008469-200410000-00004.
48. Rubio Hernández MC, Díaz Prado YI, Pérez SR, Díaz RR, Aleaga ZG. Synchronous bilateral breast cancer in a male. Ecancermedicalscience 2013;7:377. https://doi.org/10.3332/ecancer.2013.377.
49. Frión-Herrera Y, Díaz-García A, Ruiz-Fuentes J, Rodríguez-Sánchez H, Sforcin JM. The cytotoxic effects of propolis on breast cancer cells involve PI3K/Akt and ERK1/2 pathways, mitochondrial membrane potential, and reactive oxygen species generation. Inflammopharmacology 2019;27:1081-9. https://doi.org/10.1007/s10787-018-0492-y.
50. Becceneri AB, Popolin CP, Plutin AM, Maistro EL, Castellano EE, Batista AA, et al. The trans-[Ru(PPh3)2(N,N-dimethyl-N’-thiophenylthioureato-k2O,S)(bipy)]PF6 complex has pro-apoptotic effects on triple negative breast cancer cells and presents low toxicity in vivo. J Inorg Biochem 2018;186:70-84. https://doi.org/10.1016/j.jinorgbio.2018.05.011.
51. González RS. Cancer screening: global debates and Cuban experience. MEDICC Rev 2014;16:73-7. https://doi.org/10.37757/MR2014.V16.N3-4.14
Published
Issue
Section
License
Copyright (c) 2022 David José Pérez Reyes, Roberto Lardoeyt Ferrer , Martha Sonia Robaina Castellanos (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.
